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c/cagrilintide·submitted 6 months ago by u/lukas_vermeulen

[Results] 17 weeks, 6kg, and cagrilintide was the hard part

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17 weeks, 6kg, and cagrilintide was the hard part. Full detail below, and I have tried to keep the editorialising out of it. Pulling the figures out of the title: 17 weeks and 6kg. All of it is written down as it happened rather than reconstructed. Asked a question here that turned out to be based on a mechanism…

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6 comments, started 6 months ago
u/rt_shift_reggie77 points·6 months ago·edited

That is preclinical work and the thread is treating it as a human finding.

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u/tomas_kimani35 points·6 months ago

Same view — long-acting is the engineering achievement here, and it is why the molecule exists at all.

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u/hugo_pires14 points·6 months ago

Yes. The combination is where the interesting effect sizes are, and the monotherapy arms read very differently.

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u/ferran_halonen10 points·6 months ago

Small fix — amylin analogue, not a GLP-1 analogue. The whole mechanism argument changes on that word.

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u/lane_map_larrylogistics8 points·6 months ago·edited

Yes.

Adding the standing caveat — nothing here is approved standalone and research material is not for human use.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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