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c/cagrilintide·submitted 6 months ago by u/lukas_vermeulen

[Results] 17 weeks, 6kg, and cagrilintide was the hard part

Labbranch of 7 comments

17 weeks, 6kg, and cagrilintide was the hard part. Full detail below, and I have tried to keep the editorialising out of it. Pulling the figures out of the title: 17 weeks and 6kg. All of it is written down as it happened rather than reconstructed. Asked a question here that turned out to be based on a mechanism…

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7 comments, started 6 months ago
u/ms_fragmenter43 points·6 months ago

Independent purity data on this compound is sparse compared with the older molecules, simply because far fewer members have paid for testing. Sparse data means wide uncertainty, not a verdict.

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u/hana_pereira34 points·6 months ago

Correcting myself upthread: I gave the 22-week figure and the paper reports 89 weeks.

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u/niels_norgaard8 points·6 months ago

Read the combination paper twice before saying anything here. The monotherapy and combination arms tell genuinely different stories.

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u/noor_hovland6 points·6 months ago

Is there any independent purity data on this compound that you have seen?

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u/ledger_modMOD18 points·6 months ago

Independent result added to the log. Thank you for paying for it — there are very few on this compound.

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u/lucia_bruun62 points·6 months ago

the monotherapy numbers are modest and that is not the point

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u/sequence_checkerresearch peptides39 points·6 months ago

What does the tolerability table in that paper actually say?

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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