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c/cagrilintide·submitted 1 year ago by u/amara_kuipers

is it normal to get food noise at week 47

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is it normal to get food noise at week 47, and the part I actually want to talk about is at the bottom. Read the combination paper twice before saying anything here. The monotherapy and combination arms tell genuinely different stories. The tolerability tables were more informative than the headline numbers, which is…

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6 comments, started 1 year ago
u/teodor_lokken277 points·1 year ago

Dosing intuitions from the GLP-1 boards do not transfer. Different receptor family, different exposure-response, and no published schedule for members to reason from.

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u/yannick_salinas190 points·1 year ago

Yes. Anyone reading this board should hold their conclusions loosely until phase 3 reports.

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u/liv_dumitru95 points·1 year ago

What does the tolerability table in that paper actually say?

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u/yara_mensah64 points·1 year ago

amylin and GLP-1 are not redundant pathways

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u/amylin_amyamylin67 points·1 year ago

Correction: that is the combination programme, not the monotherapy readout. Different arms, different numbers.

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u/hub_opssite staff98 points·1 year ago

Correction: that is the combination programme, not the monotherapy readout.

Agreed, and the combination arms are where the interesting numbers actually live.

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