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c/bpc157·submitted 1 year ago by u/isabela_nilsen

why does nobody talk about tendon

Scepticbranch of 6 comments

The title is the whole question — why does nobody talk about tendon — but here is why I am asking. Kept a reconstituted vial too long out of curiosity and learned something about solution stability I would rather have read. Assumed regulatory status was static and it was not. Checked again this year and the answer…

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6 comments, started 1 year ago
u/elodie_yilmaz20 points·1 year ago

It is a fifteen-residue peptide with a published sequence, which makes synthesis straightforward and makes identity verification the meaningful test rather than an optional extra.

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u/ms_fragmenter16 points·1 year ago

Short peptides in solution are subject to hydrolysis and, depending on sequence, oxidation. Storage state and time in solution are practical variables that this board almost never discusses.

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u/signe_grimaldi11 points·1 year ago

It is a fifteen-residue peptide with a published sequence, which makes synthesis straightforward and makes identity verification the meaningful test r

Disagreeing with this line: that paper is in a rodent model and it is being quoted as a human result.

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u/piotr_grimaldi5 points·1 year ago

Disagreeing with this line: that paper is in a rodent model and it is being quoted as a human result.

Agreed — and the preclinical to clinical gap is where nearly all the overclaiming happens.

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u/ice_pack_auditcold chain9 points·1 year ago

a fifteen-residue peptide is easy to make and easy to make badly

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u/hplc_hobbyistruns their own column5 points·1 year ago

What jurisdiction are you asking about? The answer has changed in several.

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About c/bpc157

BPC-157 as it actually is: a pentadecapeptide with a genuinely interesting rodent tendon-and-gut literature, near-zero controlled human data, a naming and sequence mess in the supply chain, and a regulatory status that changed sharply in several countries.

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