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c/bpc157·submitted 22 days ago by u/ilias_steiner

BPC-157: the version I wish someone had shown me in week 1

Questionbranch of 12 comments

BPC-157: the version I wish someone had shown me in week 1. Numbers below. Ask me the boring questions, they are the useful ones. Kept a reconstituted vial too long out of curiosity and learned something about solution stability I would rather have read. Why identity, not purity, is the test to buy here. This is a…

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12 comments, started 21 days ago
u/ilias_kaufmann6 points·21 days ago

The published literature is overwhelmingly preclinical, largely in rodent models. Translating a rodent result into a human expectation is not a small step, and almost every confident claim here takes it silently.

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u/pavel_kimani5 points·21 days ago

Small fix — fifteen residues, not seventeen. The sequence is public and easy to check.

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u/signe_grimaldi1 point·21 days ago

identity testing matters more here than purity does

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u/signe_grimaldi1 point·21 days ago

Agreed. Identity is the question here. A short peptide can be synthesised by almost anyone and the sequence is what you are actually buying.

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u/food_noise_gonemaintenance1 point·20 days ago

identity, quantity, stability — three separate questions

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u/ms_fragmenter1 point·21 days ago

identity testing matters more here than purity does

This is the point that should be at the top of every thread here. Identity first.

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u/mei_serrano2 points·21 days ago·edited

Small fix — fifteen residues, not seventeen.

Disagreeing with this line: that paper is in a rodent model and it is being quoted as a human result.

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u/nils_ferreira3 points·20 days ago

stability in solution is the practical question nobody asks

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u/clara_danquah1 point·20 days ago

short peptides are cheap, which cuts both ways

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u/katrin_girard1 point·19 days ago

read the actual papers, they are more modest than the summaries

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u/curious_panel_only1 point·20 days ago

a fifteen-residue peptide is easy to make and easy to make badly

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u/dario_bakken1 point·21 days ago

Research-use-only material is not approved for human use. In this board that is not a formality — it is the reason the clinical evidence base is as thin as it is.

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About c/bpc157

BPC-157 as it actually is: a pentadecapeptide with a genuinely interesting rodent tendon-and-gut literature, near-zero controlled human data, a naming and sequence mess in the supply chain, and a regulatory status that changed sharply in several countries.

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