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c/bpc157·submitted 2 years ago by u/tomas_lehtinen

reading tendon threads from 2024 and half of it aged badly

Questionbranch of 7 comments

reading tendon threads from 2024 and half of it aged badly — a position I have arrived at slowly and would like tested. Regulatory classification differs between jurisdictions and has changed in several of them recently. Any answer to a status question needs a place and a date attached. Paid for identity confirmation…

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This branch

7 comments, started 2 years ago
u/canada_coverage197 points·2 years ago

Not convinced. A high purity figure with no identity confirmation tells you the sample is homogeneous, not that it is what you ordered.

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u/osman_brandt164 points·2 years ago

Not convinced.

This is the point that should be at the top of every thread here. Identity first.

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u/rui_only_ro156 points·2 years ago

The published literature is overwhelmingly preclinical, largely in rodent models. Translating a rodent result into a human expectation is not a small step, and almost every confident claim here takes it silently.

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u/baseline_drifteranalytical49 points·2 years ago

Not convinced.

Agreed — and the preclinical to clinical gap is where nearly all the overclaiming happens.

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u/kaplan_meier_kim13 points·2 years ago

a fifteen-residue peptide is easy to make and easy to make badly

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u/mariam_mensa5 points·2 years ago

Small fix — fifteen residues, not seventeen. The sequence is public and easy to check.

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u/asks_dumb_questions2 points·2 years ago·edited

Small fix — fifteen residues, not seventeen.

mariam_mensa is right that a pure something-else is still something else.

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About c/bpc157

BPC-157 as it actually is: a pentadecapeptide with a genuinely interesting rodent tendon-and-gut literature, near-zero controlled human data, a naming and sequence mess in the supply chain, and a regulatory status that changed sharply in several countries.

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Mar 2024created
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