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c/bpc157·submitted 6 months ago by u/ismael_chukwu

regulatory is the most under-discussed thing on this board

Labbranch of 19 comments

regulatory is the most under-discussed thing on this board. Change my mind, genuinely — I have no stake in being right about this. The three questions, kept separate, because this board runs them together constantly. Identity : is this the sequence I ordered? Answered by mass spectrometry against a theoretical mass.…

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This branch

19 comments, started 6 months ago
u/bpc_scepticMOD251 points·6 months ago

Left up. It distinguishes rodent work from human work, which is the standard on this board.

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[removed]180 points·6 months ago

[removed by moderator]

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u/ismael_chukwuOP131 points·6 months ago

That is a purity figure, not an identity confirmation. Two different tests and only one answers the question asked.

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u/ismael_chukwuOP99 points·6 months ago

Correcting myself: I said the regulatory position had not changed and in that jurisdiction it has.

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u/elodie_yilmaz60 points·6 months ago·edited

Yes. Nothing here is approved for human use and that should be the first line of every thread, not the last.

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u/neha_falk0 points·6 months ago

Correction: that study was in rodents. Worth stating explicitly since the thread has been reading it as clinical.

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u/pavel_kimani210 points·6 months ago

the human evidence is thin and the rodent evidence is not

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u/bence_ibarra249 points·6 months ago

identity testing matters more here than purity does

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u/meal_prep_mira88 points·6 months ago

Purity by area percent tells you the sample is homogeneous. Mass spectrometry tells you what the homogeneous thing is. For a short peptide, the second question is the one worth paying for.

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u/mariam_mensa264 points·6 months ago

Reconstituted or powder, and how long has it been in solution?

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u/yara_antonsen221 points·6 months ago·edited

Reconstituted or powder, and how long has it been in solution?

This is the point that should be at the top of every thread here. Identity first.

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u/blunt_coldbox138 points·6 months ago

stability in solution is the practical question nobody asks

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u/enzo_ferrari40 points·6 months ago

ask for the mass spectrum, not just the purity number

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u/isabela_nilsen28 points·6 months ago

read the actual papers, they are more modest than the summaries

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u/cloudy_vial_carol18 points·6 months ago

identity, quantity, stability — three separate questions

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u/viktor_laurent35 points·6 months ago

Small fix — fifteen residues, not seventeen. The sequence is public and easy to check.

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u/ahmed_iyer13 points·6 months ago·edited

Sent a vial to Janoshik: 98.2% against a claimed 98.0%, with the mass confirming the sequence. Both halves mattered to me.

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u/enzo_ferrari6 points·6 months ago

Ask for the theoretical mass alongside the measured one. It is a one-line addition to a certificate and it converts a purity claim into an identity claim.

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u/nils_ferreira206 points·6 months ago

Left up.

Adding the standing caveat — research material is not approved for human use, wherever you are.

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About c/bpc157

BPC-157 as it actually is: a pentadecapeptide with a genuinely interesting rodent tendon-and-gut literature, near-zero controlled human data, a naming and sequence mess in the supply chain, and a regulatory status that changed sharply in several countries.

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