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c/bloodwork·posted 2 years ago by u/freya_baptista

[Results] 78 weeks on 12.5mg, full numbers, ask me anything boring

Results

Check-in as promised in the title: 78 weeks on 12.5mg, full numbers, ask me anything boring.

78 weeks and 12.5mg. Those are measured, not estimated, and not rounded up in my favour.

Reference intervals are typically the central 95% of a reference population. By construction one person in twenty falls outside one on any given test without anything being wrong.

ApoB counts atherogenic particles rather than the cholesterol they carry, which is why it can diverge from LDL-C and why it is the addition most worth making.

Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.

0 up / 0 down47% upvoted8 commentsid 36yxvm10 Jan 2024

8 comments

8 in this archive, depth 3

best — the order this archive was captured in

u/no_refunds_nr2 points·2 years ago

The confounding problem, stated plainly, because this board keeps stepping on it.

Substantial weight loss moves lipids, liver enzymes, insulin sensitivity markers and several others in its own right. If you are losing weight while taking something, any change in those markers has at least two candidate explanations and you cannot separate them from your own panel.

What you can do is standardise, take a baseline, keep the series long, and be honest in your posts about what is and is not attributable. The threads that say "this compound did X to my ApoB" almost never have the design to support the claim, mine included.

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u/mikkel_kimani1 point·2 years ago

Push back: a value just outside a reference interval is a common finding in healthy people. It is a reason to repeat.

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u/yara_boateng1 point·2 years ago

Right, and weight loss itself moves several markers, so attribution is harder than these threads assume.

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u/bac_water_banditreconstitution-7 points·2 years ago

That is a non-fasting value and the interval you are comparing it against is a fasting one.

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u/baseline_drifteranalytical1 point·2 years ago

Have you taken this to whoever ordered it?

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u/noor_cardoso1 point·2 years ago

Yes — same lab, same fasting state, same rough time of day, or the comparison is doing nothing.

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u/karl_fischer_kev1 point·2 years ago

ask whether the lab changed its assay between your two draws

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u/freya_baptistaOP1 point·2 years ago·edited

Compared two draws across two labs and spent a week worrying before finding out the assays were different.

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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