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c/bloodwork·posted 2 years ago by u/constipation_club

how much of what we believe about A1c actually comes from ferritin threads

Baseline Long Haul ×5 Clean Column ×3 Receipts ×3

how much of what we believe about A1c actually comes from ferritin threads, and I want the answer with the reasoning attached rather than just the conclusion.

Compared two draws across two labs and spent a week worrying before finding out the assays were different.

Nobody here can interpret your panel and this comment is not doing so. What a board can usefully do is help you ask better questions of somebody who can.

My TSH moved and I spent a fortnight convinced I knew why. The repeat six weeks later was back in range and I had changed nothing.

Ask me anything specific. Anything general I will probably get wrong.

3,769 up / 362 down91% upvoted28 commentsid 2mzqho1 Dec 2023

28 comments

13 in this archive, depth 6

best — the order this archive was captured in

u/yara_mensah618 points·2 years ago

Substantial weight loss independently moves lipids, liver enzymes and several other markers. Attributing a change to a compound while losing weight is confounded by design.

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u/leila_vasquez383 points·2 years ago

Different laboratories use different assay platforms with different calibration. Comparing across labs adds a systematic offset that is invisible on the report.

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u/mikkel_kimani218 points·2 years ago

Same view — ApoB if you add one thing. It answers a question the standard panel only gestures at.

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[deleted]90 points·2 years ago

[deleted]

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u/lipid_panel_larrybloodwork96 points·2 years ago

ApoB is the one worth adding if you only add one

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u/ismael_eriksen32 points·2 years ago

I would not draw a line through two points, especially when the second was taken at a different time of day.

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u/milos_trevino17 points·2 years ago

weight loss itself moves several of these independently

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u/cardio_endpoint_c14 points·2 years ago

Small fix — a reference interval is not a treatment target, and the post above uses them interchangeably.

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u/micro_bump_mick3 points·2 years ago·edited

That is a non-fasting value and the interval you are comparing it against is a fasting one.

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u/kaia_kuusela201 points·2 years ago

Tracked eGFR against the weight trend for a year. The correlation was much weaker than I expected and that was worth knowing.

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u/kofi_balogun300 points·2 years ago

Same lab as the previous draw?

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u/ravi_sandvik-29 points·2 years ago

lab reference ranges are not treatment targets

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u/emeka_chowdhury1 point·2 years ago

Careful — that is a question for whoever ordered the panel, and nobody in this thread can answer it responsibly.

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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