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c/bloodwork·posted 6 months ago by u/chidi_abubakar

week 71 check-in — 23kg down, muscle cramps manageable, one thing confusing me

Question Receipts ×7 Slow Clap ×2

week 71 check-in — 23kg down, muscle cramps manageable, one thing confusing me. Posting the boring middle of the process, because the internet is full of the start and the end and nothing else.

To save the first four comments: week 71 and 23kg.

The confounding problem, stated plainly, because this board keeps stepping on it.

Substantial weight loss moves lipids, liver enzymes, insulin sensitivity markers and several others in its own right. If you are losing weight while taking something, any change in those markers has at least two candidate explanations and you cannot separate them from your own panel.

What you can do is standardise, take a baseline, keep the series long, and be honest in your posts about what is and is not attributable. The threads that say "this compound did X to my ALT" almost never have the design to support the claim, mine included.

Repeat testing before acting is standard practice for a reason: regression to the mean does a lot of work on single outlying values.

I will update this if the picture changes rather than quietly leaving it up.

2,198 up / 277 down89% upvoted46 commentsid 1yuyct3 Jan 2026

46 comments

8 in this archive, depth 4

best — the order this archive was captured in

u/thyroid_tangent156 points·6 months ago

Nobody here can interpret your panel and this comment is not doing so. What a board can usefully do is help you ask better questions of somebody who can.

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u/elin_varga81 points·6 months ago

Agreed on assay changes. A lab switching platforms between your draws is invisible unless you ask.

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u/liver_enzyme_liz39 points·6 months ago

Careful — that is a question for whoever ordered the panel, and nobody in this thread can answer it responsibly.

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u/kaia_kuusela32 points·6 months ago

That is a non-fasting value and the interval you are comparing it against is a fasting one.

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u/a1c_arcMOD42 points·6 months ago

Left up. It is a question about how to compare panels, not a request for interpretation.

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u/skip_week_sceptic11 points·6 months ago

This. Reference ranges are population intervals, not targets, and conflating them causes a lot of unnecessary alarm here.

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u/santiago_rasmussen12 points·6 months ago

ApoB counts atherogenic particles rather than the cholesterol they carry, which is why it can diverge from LDL-C and why it is the addition most worth making.

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u/neha_rahimi18 points·6 months ago

fasting state and time of day change more than people expect

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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