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c/bloodwork·posted 9 days ago by u/elise_grimaldi

[Explainer] HOMA-IR is crude and free, track it anyway

Explainer

Genuinely asking, not being difficult.

Everyone in c/meta repeats that ALT is important. I believe it, but I have never seen anyone show why, and when I search I get 12 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

29 up / 44 down40% upvoted10 commentsid 1yrpcc21 Jul 2026

10 comments

10 in this archive, depth 3

best — the order this archive was captured in

u/milos_trevino2 points·8 days ago

eGFR noise on rapid loss is real. 16 week noise, 36 week trend. Do not panic at week 24.

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u/ismael_eriksen1 point·8 days ago

eGFR noise on rapid loss is real.

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

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u/gustav_cardoso0 points·8 days ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/valeria_karlsen1 point·8 days ago
batch number?
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u/elise_grimaldiOP1 point·7 days ago

baseline is the most important eGFR measurement, you cannot collect it later

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u/elise_grimaldiOP1 point·7 days ago

eGFR noise during rapid loss is expected

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u/mariam_mensa1 point·8 days ago

the 3 month baseline labs check is the routine

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u/janek_ferrari1 point·7 days ago

Is that fasted?

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u/santiago_szabo1 point·7 days ago

ALT from 10 to 3 is movement, not noise

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u/kofi_balogun1 point·8 days ago

My triglycerides went from 4 to 32 in 39 weeks. The lipids story shows up in the trend, not the single number.

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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