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c/bloodwork·posted 3 months ago by u/ahmed_fonseca

stalled for 6 weeks at 2.5mg and I refuse to panic this time

Discussion

stalled for 6 weeks at 2.5mg and I refuse to panic this time. I have gone back and forth on this for months.

Hard numbers: 6 weeks and 2.5mg. Anything softer than that is flagged as an impression.

Nobody here can interpret your panel and this comment is not doing so. What a board can usefully do is help you ask better questions of somebody who can.

My TSH moved and I spent a fortnight convinced I knew why. The repeat six weeks later was back in range and I had changed nothing.

Happy to answer the boring questions. Those are usually the ones worth asking.

1,820 up / 1,624 down53% upvoted19 commentsid 18dfx81 May 2026

19 comments

16 in this archive, depth 5

best — the order this archive was captured in

u/gentle_correctionnice about it36 points·2 months ago

How to make a panel worth comparing, which is most of the value people leave on the table.

Standardise the conditions: same lab, same fasting state, same rough time of day, same point in the week, similar hydration. Take a baseline before you change anything. Repeat any surprising value before acting on it. Change one thing at a time if you want to attribute anything to it.

Do that and a year of panels is a trend. Skip it and a year of panels is a collection of unrelated mornings, which is what most of the alarmed posts here are actually describing.

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u/nnt_nate22 points·2 months ago

draw at the same point in the week if you want comparability

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u/ahmed_fonsecaOP8 points·2 months ago

baseline before you start is worth more than any later panel

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u/ahmed_fonsecaOP5 points·2 months ago

Brought the whole set to my clinician rather than one flagged value. Completely different conversation.

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[deleted]9 points·2 months ago

[deleted]

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u/santiago_rasmussen7 points·2 months ago

same lab, same conditions, or you are comparing noise

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u/elin_trevino2 points·2 months ago

Draw at the same point in the week now, fasting, same lab. The noise dropped enormously once I standardised.

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u/ahmed_fonsecaOP2 points·2 months ago

nothing on this board interprets your results for you

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u/milos_trevino1 point·2 months ago

one measurement is a point, two is a line, three is a trend

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u/janek_ferrari17 points·2 months ago

Repeat testing before acting is standard practice for a reason: regression to the mean does a lot of work on single outlying values.

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u/blank_injection-26 points·2 months ago

The confounding problem, stated plainly, because this board keeps stepping on it.

Substantial weight loss moves lipids, liver enzymes, insulin sensitivity markers and several others in its own right. If you are losing weight while taking something, any change in those markers has at least two candidate explanations and you cannot separate them from your own panel.

What you can do is standardise, take a baseline, keep the series long, and be honest in your posts about what is and is not attributable. The threads that say "this compound did X to my ALT" almost never have the design to support the claim, mine included.

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u/britt_marchand0 points·2 months ago

How many weeks between the two measurements?

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u/lina_almeida1 point·2 months ago

ApoB counts atherogenic particles rather than the cholesterol they carry, which is why it can diverge from LDL-C and why it is the addition most worth making.

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u/lipid_panel_larrybloodwork1 point·2 months ago

Careful — that is a question for whoever ordered the panel, and nobody in this thread can answer it responsibly.

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u/laila_yilmaz1 point·2 months ago

Not convinced by the attribution. Weight loss alone moves that marker and you have no way to separate the two.

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u/peptidemeter_pat1 point·2 months ago

assay method matters, especially between different labs

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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