reading lipids threads from 2024 and half of it aged badly
reading lipids threads from 2024 and half of it aged badly, which sounds obvious until you try to state the evidence for it. Reference intervals are typically the central 95% of a reference population. By construction one person in twenty falls outside one on any given test without anything being wrong. Different…
The confounding problem, stated plainly, because this board keeps stepping on it.
Substantial weight loss moves lipids, liver enzymes, insulin sensitivity markers and several others in its own right. If you are losing weight while taking something, any change in those markers has at least two candidate explanations and you cannot separate them from your own panel.
What you can do is standardise, take a baseline, keep the series long, and be honest in your posts about what is and is not attributable. The threads that say "this compound did X to my triglycerides" almost never have the design to support the claim, mine included.
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ApoB is the one worth adding if you only add one
fasting state and time of day change more than people expect
Substantial weight loss independently moves lipids, liver enzymes and several other markers. Attributing a change to a compound while losing weight is confounded by design.
Yes — same lab, same fasting state, same rough time of day, or the comparison is doing nothing.
Agreed. The trend is the signal. A single value is a snapshot of one morning.